Kusinthika Kwa Mafupa ndi Bioengineering

PRP yakhala ikudziwika kuti ndi plasma yomwe imakhala ndi mapulateleti apamwamba kwambiri kuposa magazi wamba.Ntchito yayikulu ya mapulateleti ndikupanga pulagi ya hemostatic ndikulimbikitsa kupanga fibrin ndi kutsekeka kwa magazi kuti magazi asatayike.Komabe, iwonso ndi mbali yofunika kwambiri ya chitetezo chachibadwa.Amalimbana ndi matenda ndikusintha kutupa, amalimbikitsa chemotaxis ya maselo ndi kuchulukana, ndipo amalimbikitsa machiritso a mabala, angiogenesis, ndi mapangidwe a mafupa.

Mkati mwa mapulateleti, gwero lochulukirapo la mapuloteni obisika ndi α-granule.Mapuloteni obisika amatha kugawidwa m'mabanja osiyanasiyana kutengera zochita zawo zamoyo.Zinthu monga PDGF, IGF-1, VEGF, ndi ma chemokines angapo ndi ma cytokines amathandizira kuchira kwa bala ndikulimbikitsa angiogenesis mogwirizana ndi oyimira pakati pa proangiogenic monga SDF-1, MMP-1, MMP-2, MMP-9, ndi angiopoietin omwe ali nawonso alipo.FGF-2 ndi mitogenic factor komanso TGF-β1 yomwe imadziwikanso kuti imatulutsa maselo otupa ku bala.IGF-1 imapangitsa kuti matrix apange. .

Ma molekyulu otupa a CD40 ligand omwe amapezeka pamapulateleti akukhulupirira kuti amagwira ntchito yofunika kwambiri polimbikitsa angiogenesis polimbikitsa kuchuluka kwa ma cell endothelial.BMP-2, BMP-4, ndi BMP-6 amapangidwa ndi megakaryocytes ndipo amamasulidwa ndi mapulateleti mu acidic hypoxic chilengedwe cha kuthyoka kwa mafupa.Zowonadi, akuti PRP imapangitsa kusiyana kwa osteoblastic kwa ma myoblasts ndi osteoblasts pamaso pa BMP-2, BMP-4, BMP-6, ndi BMP-7 mwina pochita gawo lothandizira kusiyanitsa kwa osteoblastic komwe kumadalira BMP.