Plasma: Kumvetsetsa Kwatsopano Kwantchito ndi Zolinga Zamankhwala mu 2022

Machiritso omwe akungoyamba kumene omwe amagwiritsa ntchito ma plasma olemera kwambiri a plasma (PRP) ali ndi mwayi wochita nawo mbali munjira zosiyanasiyana zamankhwala ochiritsira.Pali kufunikira kosakwanira kwapadziko lonse kwa njira zokonzetsera minofu yochizira matenda a minofu ndi mafupa (MSK) ndi matenda a msana, osteoarthritis (OA), ndi odwala omwe ali ndi mabala ovuta komanso osamva.Thandizo la PRP limachokera ku mfundo yakuti mapulateleti akumera (PGFs) amathandiza magawo atatu a machiritso a mabala ndi kukonza zowonongeka (kutupa, kufalikira, kukonzanso).

Mitundu yambiri yosiyanasiyana ya PRP yawunikidwa, yochokera ku maphunziro aumunthu, mu vitro, ndi zinyama.Komabe, malingaliro ochokera ku kafukufuku wa mu vitro ndi zinyama nthawi zambiri amabweretsa zotsatira zosiyana zachipatala chifukwa n'zovuta kumasulira zotsatira za kafukufuku wosagwirizana ndi zachipatala ndi ndondomeko za njira ku ndondomeko zachipatala za anthu.M'zaka zaposachedwa, kupita patsogolo kwachitika pakumvetsetsa ukadaulo wa PRP ndi malingaliro opangira bio, ndipo malangizo atsopano ofufuza ndi zidziwitso zatsopano zaperekedwa.Mu ndemangayi, tikambirana zomwe zachitika posachedwa ponena za kukonzekera kwa PRP ndi kapangidwe kake pa mlingo wa platelet, ntchito za leukocyte zokhudzana ndi innate and adaptive immunomodulation, serotonin (5-HT) zotsatira, ndi kupha ululu.Kuphatikiza apo, timakambirana njira za PRP zokhudzana ndi kutupa ndi angiogenesis pakukonzanso minofu ndi njira zotsitsimutsa.Potsirizira pake, tidzawonanso zotsatira za mankhwala ena pa ntchito ya PRP, ndi kuphatikiza kwa PRP ndi ndondomeko zokonzanso.

PRP Terminology ndi Classification

Kupanga zinthu za PRP kuti zilimbikitse kukonza ndi kusinthika kwa minofu kwakhala gawo lofunikira lofufuzira mu sayansi ya biomaterial ndi mankhwala kwazaka zambiri.Kuchiritsa kwa minofu kumaphatikizapo osewera ambiri, kuphatikiza mapulateleti omwe ali ndi kukula kwawo ndi ma cytokine granules, leukocytes, matrix a fibrin, ndi ma cytokines ena ambiri, omwe amagwira ntchito mogwirizana.Pakuphulika uku, njira yovuta yolumikizirana imachitika, yomwe imaphatikizapo kutsegulira kwa mapulateleti ndikutulutsidwa kotsatira kwa zomwe zili mumagulu owundana ndi α-platelet, polymerization ya fibrinogen (yotulutsidwa ndi mapulateleti kapena yaulere mu plasma) kukhala mauna a fibrin, ndi chitukuko cha pulagi ya mapulateleti. .